Godier Anne, Roberts Ian, Hunt Beverley J
Crit Care. 2012 Jun 29;16(3):135. doi: 10.1186/cc11374.
The early administration of tranexamic acid (TXA) to bleeding trauma patients reduces all-cause mortality without increasing the risk of vascular occlusive events. Indeed, the risk of arterial thrombosis appears to be reduced with TXA. In this commentary we hypothesize that TXA has an antithrombotic effect and explore potential mechanisms. These include inhibition of the inflammatory effects of plasmin, effects on platelets and effects on factors V and VIII. If proven, these antithrombotic effects would have major implications for the systemic use of TXA in surgical patients, where TXA has been clearly shown to reduce bleeding.
对出血性创伤患者早期使用氨甲环酸（TXA）可降低全因死亡率，且不会增加血管闭塞事件的风险。事实上，TXA似乎可降低动脉血栓形成的风险。在本评论中，我们推测TXA具有抗血栓形成作用，并探讨其潜在机制。这些机制包括抑制纤溶酶的炎症作用、对血小板的作用以及对因子V和VIII的作用。如果得到证实，这些抗血栓形成作用将对TXA在外科手术患者中的全身应用产生重大影响，因为TXA已被明确证明可减少出血。
