Yerkes National Primate Research Center, Emory University, & Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30329, United States.
Cytokine Growth Factor Rev. 2012 Aug-Oct;23(4-5):223-31. doi: 10.1016/j.cytogfr.2012.05.009. Epub 2012 Jun 28.
The complex pathogenesis of HIV and SIV infections involves the activation, dysfunction, and increased turnover of numerous immune cell subsets. Myeloid cells, including monocytes, macrophages, and myeloid dendritic cells (mDCs), are a particularly relevant cell type capable of providing targets for virus infection as well as a source of immunomodulatory cytokines and chemokines. Here, we review recent literature about the interplay between HIV/SIV and myeloid cells, including viral infection, type I interferon signaling, and the contribution of myeloid cells to HIV-associated immune activation. Understanding the cytokine and chemokine networks in which monocytes, macrophages, and mDCs participate during HIV infection may yield new insights into the pathogenesis of the disease.
HIV 和 SIV 感染的复杂发病机制涉及众多免疫细胞亚群的激活、功能障碍和增加的更替。髓样细胞，包括单核细胞、巨噬细胞和髓样树突状细胞 (mDC)，是一种特别相关的细胞类型，能够提供病毒感染的靶标，以及免疫调节细胞因子和趋化因子的来源。在这里，我们回顾了最近关于 HIV/SIV 与髓样细胞相互作用的文献，包括病毒感染、I 型干扰素信号转导以及髓样细胞对 HIV 相关免疫激活的贡献。了解单核细胞、巨噬细胞和 mDC 在 HIV 感染过程中参与的细胞因子和趋化因子网络，可能为该疾病的发病机制提供新的见解。
