Unité de Prévention Cardiovasculaire, Service d'Endocrinologie Métabolisme, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, France; UPMC Université Paris 06, UMR S 939, F-75013, France.
Nutr Metab Cardiovasc Dis. 2013 Sep;23(9):871-5. doi: 10.1016/j.numecd.2012.04.012. Epub 2012 Jun 29.
To assess the burden of statin related muscular symptom in real life.
We conducted a wide survey on 10,409 French subjects. Among these, 2850 (27%) had hypercholesterolemia and 1074 were treated with statins. Muscular symptoms were reported by 104 (10%) statin treated patients and led to discontinuation in 30% of the symptomatic patients. The main prescribed statins were low doses rosuvastatin, atorvastatin and simvastatin. Pains were the most commonly described symptoms (87%) but many patients also reported stiffness (62%), cramps (67%), weakness or a loss of strength during exertion (55%). Pain was localized in 70% but mostly described as affecting several muscular groups. Approximately 38% of patients reported that their symptoms prevented even moderate exertion during everyday activities, while 42% of patients suffered major disruption to their everyday life.
Muscular symptoms associated with average dosage statin therapy are more frequent than in clinical trials and have a greater impact on patients' life than usually thought.
评估他汀类药物相关肌肉症状在真实世界中的负担。
我们对 10409 名法国受试者进行了广泛调查。其中，2850 名（27%）患有高胆固醇血症，1074 名接受他汀类药物治疗。104 名（10%）接受他汀类药物治疗的患者报告出现肌肉症状，其中 30%的症状患者因此停药。主要开具的他汀类药物为低剂量瑞舒伐他汀、阿托伐他汀和辛伐他汀。疼痛是最常描述的症状（87%），但许多患者还报告有僵硬（62%）、痉挛（67%）、乏力或用力时无力（55%）。疼痛部位有 70%是局部的，但大多描述为影响多个肌肉群。约 38%的患者报告称，他们的症状甚至妨碍了日常活动中的适度活动，而 42%的患者日常生活受到严重干扰。
与常规剂量他汀类药物治疗相关的肌肉症状比临床试验中更为常见，对患者的生活影响也比通常认为的更大。
