用于抑郁症的深部脑刺激的临床前研究模型。
Preclinical studies modeling deep brain stimulation for depression.
机构信息
Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
出版信息
Biol Psychiatry. 2012 Dec 1;72(11):916-23. doi: 10.1016/j.biopsych.2012.05.024. Epub 2012 Jun 29.
Abstract
Deep brain stimulation (DBS) is currently being investigated for the treatment of depression. Results of early clinical trials have been very promising, but the mechanisms responsible for the effects of DBS are still unknown. This article reviews behavioral findings of stimulation applied to different brain targets in rodents, with a particular focus on the ventromedial prefrontal cortex. Mechanisms and substrates involved in the antidepressant-like effects of DBS, including the role of local tissue inactivation, the modulation of fiber pathways in the vicinity of the electrodes, as well as the importance of the serotonergic system and brain derived neurotrophic factor are discussed.
摘要
深部脑刺激 (DBS) 目前正在被研究用于治疗抑郁症。早期临床试验的结果非常有希望，但 DBS 作用的机制仍不清楚。本文综述了刺激不同脑靶点在啮齿类动物中的行为学发现，特别关注腹内侧前额叶皮层。讨论了 DBS 抗抑郁样作用的机制和底物，包括局部组织失活的作用、电极附近纤维通路的调制，以及 5-羟色胺能系统和脑源性神经营养因子的重要性。
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