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2
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3
Deep brain stimulation for treatment-resistant depression: an integrative review of preclinical and clinical findings and translational implications.深部脑刺激治疗难治性抑郁症：临床前和临床研究结果及转化意义的综合综述。
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Deep brain stimulation changes locus coeruleus responses to social stress from activation to inhibition.深部脑刺激改变了蓝斑对社会压力的反应，从激活变为抑制。
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Serotonin 5-HT receptors mediate the antidepressant- and anxiolytic-like effects of ventromedial prefrontal cortex deep brain stimulation in a mouse model of social defeat.在社会挫败小鼠模型中，5-羟色胺5-羟色胺受体介导腹内侧前额叶皮质深部脑刺激的抗抑郁样和抗焦虑样作用。
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本文引用的文献

1
Deep brain stimulation for psychiatric disease: contributions and validity of animal models.精神疾病的深部脑刺激：动物模型的贡献和有效性。
Sci Transl Med. 2012 Jul 11;4(142):142rv8. doi: 10.1126/scitranslmed.3003722.
2
Subcallosal cingulate deep brain stimulation for treatment-resistant unipolar and bipolar depression.胼胝体下扣带回深部脑刺激治疗难治性单相和双相抑郁症。
Arch Gen Psychiatry. 2012 Feb;69(2):150-8. doi: 10.1001/archgenpsychiatry.2011.1456. Epub 2012 Jan 2.
3
A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression.一项针对难治性抑郁症的扣带回下深部脑刺激的多中心先导研究。
J Neurosurg. 2012 Feb;116(2):315-22. doi: 10.3171/2011.10.JNS102122. Epub 2011 Nov 18.
4
Deep brain stimulation reverses anhedonic-like behavior in a chronic model of depression: role of serotonin and brain derived neurotrophic factor.深部脑刺激可逆转慢性抑郁模型中的快感缺失样行为：5-羟色胺和脑源性神经营养因子的作用。
Biol Psychiatry. 2012 Jan 1;71(1):30-5. doi: 10.1016/j.biopsych.2011.08.025. Epub 2011 Oct 14.
5
Chronic deep brain stimulation of the lateral habenula nucleus in a rat model of depression.慢性外侧缰核深部脑刺激治疗抑郁模型大鼠。
Brain Res. 2011 Nov 8;1422:32-8. doi: 10.1016/j.brainres.2011.08.041. Epub 2011 Aug 22.
6
Vulnerability to depression: from brain neuroplasticity to identification of biomarkers.易患抑郁症：从大脑神经可塑性到生物标志物的鉴定。
J Neurosci. 2011 Sep 7;31(36):12889-99. doi: 10.1523/JNEUROSCI.1309-11.2011.
7
Deep brain stimulation of the subcallosal cingulate gyrus: further evidence in treatment-resistant major depression.扣带回下脚深部脑刺激：治疗抵抗性重度抑郁症的进一步证据。
Int J Neuropsychopharmacol. 2012 Feb;15(1):121-33. doi: 10.1017/S1461145711001088. Epub 2011 Jul 22.
8
Rules ventral prefrontal cortical axons use to reach their targets: implications for diffusion tensor imaging tractography and deep brain stimulation for psychiatric illness.规则腹侧前额皮质轴突到达其目标：对精神疾病扩散张量成像轨迹和深部脑刺激的影响。
J Neurosci. 2011 Jul 13;31(28):10392-402. doi: 10.1523/JNEUROSCI.0595-11.2011.
9
An evaluation of neuroplasticity and behavior after deep brain stimulation of the nucleus accumbens in an animal model of depression.评价在抑郁动物模型中进行伏隔核深部脑刺激后的神经可塑性和行为。
Neurosurgery. 2011 Dec;69(6):1281-90. doi: 10.1227/NEU.0b013e3182237346.
10
Resilience to chronic stress is mediated by hippocampal brain-derived neurotrophic factor.慢性应激的抵抗力是由海马脑源性神经营养因子介导的。
J Neurosci. 2011 Mar 23;31(12):4475-83. doi: 10.1523/JNEUROSCI.5725-10.2011.

用于抑郁症的深部脑刺激的临床前研究模型。

Preclinical studies modeling deep brain stimulation for depression.

机构信息

Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

出版信息

Biol Psychiatry. 2012 Dec 1;72(11):916-23. doi: 10.1016/j.biopsych.2012.05.024. Epub 2012 Jun 29.

DOI:10.1016/j.biopsych.2012.05.024
PMID:22748616
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5633367/
Abstract

Deep brain stimulation (DBS) is currently being investigated for the treatment of depression. Results of early clinical trials have been very promising, but the mechanisms responsible for the effects of DBS are still unknown. This article reviews behavioral findings of stimulation applied to different brain targets in rodents, with a particular focus on the ventromedial prefrontal cortex. Mechanisms and substrates involved in the antidepressant-like effects of DBS, including the role of local tissue inactivation, the modulation of fiber pathways in the vicinity of the electrodes, as well as the importance of the serotonergic system and brain derived neurotrophic factor are discussed.

摘要

深部脑刺激 (DBS) 目前正在被研究用于治疗抑郁症。早期临床试验的结果非常有希望，但 DBS 作用的机制仍不清楚。本文综述了刺激不同脑靶点在啮齿类动物中的行为学发现，特别关注腹内侧前额叶皮层。讨论了 DBS 抗抑郁样作用的机制和底物，包括局部组织失活的作用、电极附近纤维通路的调制，以及 5-羟色胺能系统和脑源性神经营养因子的重要性。