Davidson Benjamin, Lipsman Nir, Meng Ying, Rabin Jennifer S, Giacobbe Peter, Hamani Clement
Sunnybrook Research Institute, Toronto, ON, Canada.
Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Front Hum Neurosci. 2020 Nov 16;14:588423. doi: 10.3389/fnhum.2020.588423. eCollection 2020.
Deep Brain Stimulation (DBS) has been investigated as a treatment option for patients with refractory psychiatric illness. Over the past two decades, neuroimaging developments have helped to advance the field, particularly the use of diffusion tensor imaging (DTI) and tractographic reconstruction of white-matter pathways. In this article, we review translational considerations and how DTI and tractography have been used to improve targeting during DBS surgery for depression, obsessive compulsive disorder (OCD) and post-traumatic stress disorder (PTSD).
深部脑刺激（DBS）已被作为难治性精神疾病患者的一种治疗选择进行研究。在过去二十年中，神经影像学的发展推动了该领域的进步，尤其是扩散张量成像（DTI）和白质通路的纤维束成像重建技术的应用。在本文中，我们回顾了转化医学方面的考量因素，以及DTI和纤维束成像如何被用于改善抑郁症、强迫症（OCD）和创伤后应激障碍（PTSD）患者DBS手术中的靶点定位。
