Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
J Formos Med Assoc. 2012 Jun;111(6):347-9. doi: 10.1016/j.jfma.2009.09.001. Epub 2012 May 14.
Crohn disease is a chronic inflammatory disorder, which is rare in pediatric patients. The definite etiology and mechanism to induce an acute exacerbation of Crohn disease remains mostly unknown. The authors report on a 14-year-old girl with Crohn disease who has acute gastrointestinal symptoms caused by toxin A-producing Clostridium difficile, which mimicked a flare-up of Crohn disease. There was no preceding antibiotic prescription before the episode. The disease activity did not improve after steroid treatment, which is unusual for Crohn disease. However, all symptoms were dramatically relieved after eradication of C difficile, and led to a symptom-free period for more than 3 years. This case report aims to address the unusual presentation of a usual pathogen, C difficile, in a pediatric patient with Crohn disease.
克罗恩病是一种慢性炎症性疾病，在儿科患者中较为罕见。导致克罗恩病急性加重的确切病因和机制尚不完全清楚。作者报告了一例 14 岁克罗恩病女孩，因产毒素 A 的艰难梭菌引起急性胃肠道症状，类似于克罗恩病发作。在此之前没有使用过抗生素。疾病活动在类固醇治疗后没有改善，这在克罗恩病中并不常见。然而，艰难梭菌被根除后，所有症状都明显缓解，并且在 3 年多的时间里没有出现症状。本病例报告旨在探讨儿科克罗恩病患者中常见病原体艰难梭菌的不常见表现。
