Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Int Rev Neurobiol. 2012;102:207-47. doi: 10.1016/B978-0-12-386986-9.00009-0.
Neurotrophic factors (NTFs) represent one of the most stimulating challenge in neurodegenerative diseases, due to their potential in neurorestoring and neuroprotection. Despite the large number of proofs-of-concept and evidences of their activity, most of the clinical trials, mainly regarding Parkinson's disease and Alzheimer's disease, demonstrated several failures of the therapeutic intervention. A large number of researches were conducted on this hot topic of neuroscience, clearly evidencing the advantages of NTF approach, but evidencing the major limitations in its application. The inability in crossing the blood-brain barrier and the lack of selectivity actually represent some of the most highlighted limits of NTFs-based therapy. In this review, beside an overview of NTF activity versus the main neuropathological disorders, a summary of the most relevant approaches, from invasive to noninvasive strategies, applied for improving NTF delivery to the central nervous systems is critically considered and evaluated.
神经营养因子（NTFs）是神经退行性疾病中最具挑战性的研究之一，因为它们具有神经修复和神经保护的潜力。尽管有大量的概念验证和活动证据，但大多数临床试验，主要是关于帕金森病和阿尔茨海默病的临床试验，都显示出治疗干预的多次失败。在这个神经科学的热门课题上进行了大量的研究，清楚地表明了 NTF 方法的优势，但也表明了其应用的主要局限性。无法穿过血脑屏障和缺乏选择性实际上是 NTF 为基础的治疗方法最突出的限制之一。在这篇综述中，除了概述 NTF 活性与主要神经病理学疾病的关系外，还批判性地考虑和评估了从侵袭性到非侵袭性策略的最相关方法，以改善 NTF 向中枢神经系统的传递。
