Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA, USA.
Regul Toxicol Pharmacol. 2012 Oct;64(1):134-42. doi: 10.1016/j.yrtph.2012.06.008. Epub 2012 Jun 28.
Exposure to chemicals occurs often as mixtures. Presented in this paper is information on alkoxyethanols and the impact they might have on human health in combination with some commonly found aliphatic and aromatic compounds. Our studies to evaluate the joint toxicity of these chemicals among themselves and in combination with other chemicals reveal a variety of possible outcomes depending on the exposure scenario. The interactions are predominantly based on metabolic pathways and are common among several solvents and organic compounds. Quantitative structure activity relationship (QSAR) analysis can be used with high confidence to identify chemicals that will interact to influence overall joint toxicity. Potential human exposure to a combination of alkoxyethanol, toluene and substituted benzenes may increase reproductive and developmental disease conditions. Inheritable gene alterations result in changes in the enzyme function in different subpopulations causing variations in quantity and/or quality of particular isoenzymes. These changes are responsible for differential metabolism of chemicals in species, genders, and life stages and are often the basis of a population's susceptibility. Unique genotypes introduced as a function of migration can alter the genetic makeup of any given population. Hence special consideration should be given to susceptible populations while conducting chemical health risk assessments.
接触化学物质通常是混合物。本文介绍了烷氧基乙醇的信息，以及它们与一些常见的脂肪族和芳香族化合物结合时可能对人类健康造成的影响。我们的研究评估了这些化学物质之间以及与其他化学物质联合的联合毒性，结果表明根据暴露情况，可能会产生各种不同的结果。这些相互作用主要基于代谢途径，在几种溶剂和有机化合物中很常见。定量构效关系（QSAR）分析可用于高度置信地识别可能相互作用影响整体联合毒性的化学物质。潜在的人类接触烷氧基乙醇、甲苯和取代苯的混合物可能会增加生殖和发育疾病的发生。可遗传的基因突变导致不同亚群中酶功能的改变，从而导致特定同工酶的数量和/或质量发生变化。这些变化负责物种、性别和生命阶段中化学物质的差异代谢，通常是种群易感性的基础。由于迁移而引入的独特基因型会改变任何特定种群的遗传组成。因此，在进行化学健康风险评估时，应特别关注易感人群。
