Aquatic Biotechnology Center of WCU Project, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, South Korea.
Dev Comp Immunol. 2012 Oct;38(2):295-301. doi: 10.1016/j.dci.2012.06.005. Epub 2012 Jun 28.
The epidermal secretion of fish contains various non-specific immune substances that act as the first line of defense against invading pathogens. The present study investigated the level of mucosal antibodies, the activities of hemagglutinin and protease, and other enzymes in the skin mucus of farm reared olive flounder (Paralichthys olivaceus) for 1 year, in order to gain an insight into the relationship between these mucosal immune substances and their seasonal variation. These levels varied significantly during different months of sample collection. The present study showed a positive correlation between water temperature and the level of mucosal antibodies, and an inverse relationship between the level of mucosal antibodies and the activity of mucosal hemagglutinin and protease, but no relationship between lysozyme activity and other innate immune substances. This relationship is thought to be a compensatory response in olive flounder to protect itself against pathogenic microorganisms which are inherently present in the aquatic environment.
鱼类的表皮分泌物中含有各种非特异性免疫物质，作为抵御入侵病原体的第一道防线。本研究调查了养殖 1 年的养殖牙鲆（Paralichthys olivaceus）皮肤黏液中的黏膜抗体水平、血凝素和蛋白酶等酶的活性，以了解这些黏膜免疫物质与季节性变化的关系。在不同的采样月份，这些水平有显著差异。本研究表明，黏膜抗体水平与水温呈正相关，与黏膜血凝素和蛋白酶活性呈负相关，但与溶菌酶活性和其他先天免疫物质无相关性。这种关系被认为是牙鲆对水生环境中固有存在的致病微生物的一种保护自身的补偿反应。
