Watson T D, Packard C J, Shepherd J, Fowler J N
Department of Veterinary Medicine, University of Glasgow Veterinary School, Bearsden.
Vet Rec. 1990 Nov 17;127(20):498-500.
Obese donkeys are susceptible to a hyperlipaemic crisis characterised by high plasma triglyceride concentrations. In this study, the relationships between the body condition of 24 donkeys and their basal lipid metabolism were investigated. Plasma cholesterol, triglyceride and lipoprotein cholesterol concentrations were measured in healthy donkeys classified according to their body condition as thin, ideal or obese. There were significant differences between the groups in the concentrations of triglyceride and very low density lipoprotein (VLDL), which increased in concentration with body condition (P less than 0.05). Cholesterol, low density lipoprotein (LDL) and high density lipoprotein (HDL) concentrations were similar in all the groups. Triglyceride and VLDL concentrations were positively correlated with body weight (r = 0.82) and plasma free fatty acid concentration (r = 0.48). There were no significant differences in basal plasma concentrations of insulin or cortisol. These results suggest that obesity in donkeys is associated with changes in lipid and lipoprotein metabolism that might predispose the animals to hyperlipaemia.
肥胖的驴易患以血浆甘油三酯浓度升高为特征的高脂血症危机。在本研究中，调查了24头驴的身体状况与其基础脂质代谢之间的关系。对根据身体状况分为瘦、理想或肥胖的健康驴测量了血浆胆固醇、甘油三酯和脂蛋白胆固醇浓度。各组之间甘油三酯和极低密度脂蛋白（VLDL）的浓度存在显著差异，其浓度随身体状况增加（P小于0.05）。所有组的胆固醇、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）浓度相似。甘油三酯和VLDL浓度与体重（r = 0.82）和血浆游离脂肪酸浓度（r = 0.48）呈正相关。基础血浆胰岛素或皮质醇浓度无显著差异。这些结果表明，驴的肥胖与脂质和脂蛋白代谢的变化有关，这可能使动物易患高脂血症。
