Deschênes Daniel, Couture Patrick, Dupont Pierre, Tchernof André
Molecular Endocrinology and Oncology Research Center, Laval University Medical Research Center, Québec, Canada.
Obes Res. 2003 Mar;11(3):469-76. doi: 10.1038/oby.2003.64.
The aim of this study was to compare the relative importance of computed tomography-measured abdominal fat compartment areas, including adipose tissue located posterior to the subcutaneous Fascia, in predicting plasma lipid-lipoprotein alterations.
Areas of visceral as well as subcutaneous deep and superficial abdominal adipose tissue were measured by computed tomography in a sample of 66 healthy women, ages 37 to 60 years, for whom a detailed lipid-lipoprotein profile was available.
Strong significant associations were observed between visceral adipose tissue area and most variables of the lipid-lipoprotein profile (r = -0.25, p < 0.05 to 0.62, p < 0.0001). Measures of hepatic lipoprotein synthesis such as very-low-density lipoprotein-triglyceride and cholesterol content as well as total and very-low-density lipoprotein-apolipoprotein B levels were also strongly associated with visceral adipose tissue area (r = 0.57, 0.57, 0.61, and 0.62, respectively, p < 0.0001). Significant associations were found between these variables and the deep subcutaneous adipose tissue area or DXA-measured total body fat mass. However, the correlation coefficients were of lower magnitude compared to those with visceral adipose tissue area. Multivariate regression analyses demonstrated that visceral adipose tissue area was the strongest predictor of lipid-lipoprotein profile variables (7% to 48% explained variance, 0.02 > or = p < or = 0.0001).
Although previous studies have generated controversial data as to which abdominal adipose tissue compartment was more closely associated with insulin resistance, our results suggest that visceral adipose tissue area is a stronger correlate of other obesity-related outcomes such as lipid-lipoprotein alterations.
本研究旨在比较计算机断层扫描测量的腹部脂肪隔室面积（包括皮下筋膜后方的脂肪组织）在预测血浆脂质 - 脂蛋白改变方面的相对重要性。
对66名年龄在37至60岁的健康女性样本进行计算机断层扫描，测量其内脏以及腹部皮下深层和浅层脂肪组织的面积，这些女性均有详细的脂质 - 脂蛋白谱数据。
观察到内脏脂肪组织面积与脂质 - 脂蛋白谱的大多数变量之间存在强显著相关性（r = -0.25，p < 0.05至0.62，p < 0.0001）。肝脏脂蛋白合成指标，如极低密度脂蛋白甘油三酯和胆固醇含量以及总极低密度脂蛋白和载脂蛋白B水平，也与内脏脂肪组织面积密切相关（分别为r = 0.57、0.57、0.61和0.62，p < 0.0001）。这些变量与深层皮下脂肪组织面积或双能X线吸收法测量的全身脂肪量之间也存在显著相关性。然而，与内脏脂肪组织面积的相关系数相比，其幅度较低。多变量回归分析表明，内脏脂肪组织面积是脂质 - 脂蛋白谱变量的最强预测因子（解释方差为7%至48%，0.02≥p≤0.0001）。
尽管先前的研究对于哪个腹部脂肪组织隔室与胰岛素抵抗更密切相关产生了有争议的数据，但我们的结果表明，内脏脂肪组织面积与其他肥胖相关结局（如脂质 - 脂蛋白改变）的相关性更强。
