立体选择性的分子间 C-H 氨化反应。
Stereoselective intermolecular C-H amination reactions.
机构信息
Département de chimie et Centre en chimie verte et catalyse, Université de Montréal, 2900 Boul. Edouard Montpetit, Montréal, Québec, Canada.
出版信息
Chem Commun (Camb). 2012 Aug 14;48(63):7799-801. doi: 10.1039/c2cc33689h. Epub 2012 Jun 29.
PMID:22751570
Abstract
A novel chiral N-mesyloxycarbamate to perform rhodium-catalyzed stereoselective C-H amination reactions is reported. Chiral benzylic and propargylic amines are produced in good yields and selectivities using ethyl acetate as solvent. The corresponding free amines are easily obtained by cleavage of the chiral reagent, which could also be recovered.
摘要
一种新型的手性 N-甲氧基羰基氨基甲酸酯被用于进行铑催化的立体选择性 C-H 胺化反应。使用乙酸乙酯作为溶剂，可以以良好的收率和选择性得到手性苄基和炔丙基胺。通过手性试剂的裂解，可以很容易地得到相应的游离胺，手性试剂也可以回收。
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