State Key Laboratory for Chirosciences and The Open Laboratory for Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong.
Org Lett. 2012 Jan 6;14(1):272-5. doi: 10.1021/ol203046n. Epub 2011 Dec 13.
A Rh(III)-catalyzed direct aromatic C-H amination is achieved using N-chloroamines as a reagent. Furthermore, we also developed a one-pot amination protocol involving in situ chlorination of the secondary amines. The catalytic amination operates at mild conditions with excellent functional group tolerance and regioselectivity.
一种使用 N-氯代胺作为试剂的 Rh(III)催化的直接芳香族 C-H 胺化反应被实现。此外，我们还开发了一种涉及仲胺原位氯化的一锅法胺化方案。该催化胺化反应在温和条件下进行，具有极好的官能团容忍性和区域选择性。
