Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital, Huddinge, Karolinska Institutet, 141 86 Stockholm, Sweden.
Eur J Clin Pharmacol. 2013 Mar;69(3):565-71. doi: 10.1007/s00228-012-1338-y. Epub 2012 Jul 1.
To investigate the impact of the integration of the drug-drug interaction database SFINX into primary health care records on the prevalence of potentially serious drug-drug interactions.
The study was a controlled before-and-after study on the prevalence of potential drug-drug interactions before and after the implementation of SFINX at 15 primary healthcare centres compared with 5 centres not receiving the intervention. Data on dispensed prescriptions from health care centres were retrieved from the Swedish prescribed drug register and analysed for September-December 2006 (pre-intervention) and September-December 2007 (post-intervention). All drugs dispensed during each 4 month period were regarded as potentially interacting.
Use of SFINX was associated with a 17% decrease, to 1.81 × 10(-3) from 2.15 × 10(-3) interactions per prescribed drug-drug pair, in the prevalence of potentially serious drug-drug interactions (p = 0.042), whereas no significant effect was observed in the control group. The change in prevalence of potentially serious drug-drug interactions did not differ significantly between the two study groups. The majority of drug-drug interactions identified were related to chelate formation.
Prescriptions resulting in potentially serious drug-drug interactions were significantly reduced after integration of the drug-drug interaction database SFINX into electronic health records in primary care. Further studies are needed to demonstrate the effectiveness of drug-drug interaction warning systems.
研究将药物相互作用数据库 SFINX 整合到初级保健记录中对潜在严重药物相互作用的发生率的影响。
本研究是一项在 15 个初级保健中心实施 SFINX 前后与未接受干预的 5 个中心进行的潜在药物相互作用发生率的对照前后研究。从瑞典处方药物登记处检索了各保健中心配药处方的数据，并对 2006 年 9 月至 12 月（干预前）和 2007 年 9 月至 12 月（干预后）进行了分析。每个 4 个月期间配药的所有药物均被视为可能相互作用。
SFINX 的使用与潜在严重药物相互作用的发生率下降了 17%，从每对配药药物的 2.15×10(-3)次交互作用降至 1.81×10(-3)次交互作用（p=0.042），而对照组未观察到显著效果。两组研究中潜在严重药物相互作用发生率的变化无显著差异。确定的药物相互作用大多数与螯合形成有关。
将药物相互作用数据库 SFINX 整合到初级保健电子健康记录中后，潜在严重药物相互作用的处方显著减少。需要进一步研究来证明药物相互作用警告系统的有效性。
