Division of Cardiovascular Research, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Protein Cell. 2012 Jun;3(6):410-8. doi: 10.1007/s13238-012-2921-9. Epub 2012 Jul 1.
Mitochondria are subcellular organelles that provide energy for the cell. They form a dynamic tubular network and play an important role in maintaining the cell function and integrity. Heart is a powerful organ that supplies the motivation for circulation, thereby requiring large amounts of energy. Thus, the healthiness of cardiomyocytes and mitochondria is necessary for the normal cardiac function. Mitochondria not only lie in the center of the cell apoptotic pathway, but also are the major source of reactive oxygen species (ROS) generation. Mitochondrial morphological change includes fission and fusion that are regulated by a large number of proteins. In this review we discuss the regulators of mitochondrial fission/fusion and their association with cell apoptosis, autophagy and ROS production in the heart.
线粒体是为细胞提供能量的细胞器。它们形成一个动态的管状网络，在维持细胞功能和完整性方面发挥着重要作用。心脏是一个提供循环动力的强大器官，因此需要大量的能量。因此，心肌细胞和线粒体的健康对于心脏的正常功能是必要的。线粒体不仅位于细胞凋亡途径的中心，也是活性氧（ROS）产生的主要来源。线粒体的形态变化包括分裂和融合，它们受大量蛋白质的调节。在这篇综述中，我们讨论了线粒体分裂/融合的调节剂及其与心脏细胞凋亡、自噬和 ROS 产生的关系。
