来自小果野桐种子的贝壳杉烷型二萜及其抗肿瘤活性。
Cassane-type diterpenes from the seeds of Caesalpinia minax with their antineoplastic activity.
机构信息
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
出版信息
Planta Med. 2012 Aug;78(12):1363-9. doi: 10.1055/s-0032-1314976. Epub 2012 Jun 29.
Five new cassane-type diterpenes, neocaesalpin AA (1), neocaesalpin AB (2), neocaesalpin AC (3), neocaesalpin AD (4) and neocaesalpin AE (5), were isolated from Caesalpinia minax together with three known compounds, 12α-methoxyl,5α,14β-dihydroxy-1α,6α,7β-triacetoxycass-13(15)-en-16,12-olide (6), spirocaesalmin (7) and magnicaesalpin (8). Their structures were elucidated based on 1D and 2D NMR, MS and CD analyses. Compounds 1-6 were tested against Hela, HCT-8, HepG-2, MCF-7 and A549 cancer cells and showed moderate cytotoxicity with IC₅₀ values from 18.4 to 83.9 µM.
从 Minax 山槟榔中分离得到五个新的贝壳杉烷二萜，分别为 neocaesalpin AA（1）、neocaesalpin AB（2）、neocaesalpin AC（3）、neocaesalpin AD（4）和 neocaesalpin AE（5），此外还分离得到三个已知化合物，12α-甲氧基、5α、14β-二羟基-1α、6α、7β-三乙酰氧基贝壳杉-13（15）-烯-16,12-内酯（6）、螺山槟榔碱（7）和 magnicaesalpin（8）。基于 1D 和 2D NMR、MS 和 CD 分析确定了它们的结构。化合物 1-6 对 Hela、HCT-8、HepG-2、MCF-7 和 A549 癌细胞进行了测试，显示出中等的细胞毒性，IC₅₀ 值范围为 18.4 到 83.9 µM。
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