Estève C, Murat I, Saint-Maurice C
Department of Paediatric Anaesthesia, Hopital Saint Vincent de Paul, Paris, France.
Acta Anaesthesiol Scand. 1990 Nov;34(8):662-4. doi: 10.1111/j.1399-6576.1990.tb03168.x.
The efficacy of flunitrazepam (0.04 mg.kg-1) as a premedicant was evaluated in 40 young children of less than 5 years of age in a double-blind, placebo-controlled study. Flunitrazepam was given by the rectal route 15 min prior to an inhalational mask induction with halothane. Sedation score, mask acceptance and induction score were significantly better in premedicated children than in the placebo group. There were no hypoxic episodes, prolonged sedation or other complications in either group. This suggests that flunitrazepam administered rectally in a low dose is an acceptable premedication in young children.
在一项双盲、安慰剂对照研究中，对40名5岁以下幼儿评估了氟硝西泮（0.04毫克/千克）作为术前用药的疗效。在使用氟烷通过面罩吸入诱导麻醉前15分钟，经直肠给予氟硝西泮。用药儿童的镇静评分、面罩接受度和诱导评分显著优于安慰剂组。两组均未出现缺氧发作、镇静时间延长或其他并发症。这表明低剂量经直肠给予氟硝西泮是幼儿可接受的术前用药。
