Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, Arizona, USA.
Pediatrics. 2012 Aug;130(2):e432-8. doi: 10.1542/peds.2011-2511. Epub 2012 Jul 2.
In recent years, intravenous lipid emulsion (ILE) therapy has emerged as a new rescue antidote for treatment of certain toxicities, including cyclic antidepressants, and as the primary treatment of toxic manifestations after local anesthetic exposure. We present a case of a 13-year-old girl who developed delayed seizures and cardiac arrest after amitriptyline ingestion. As part of the treatment, she was treated with ILE therapy. The patient's laboratories were not interpretable for several hours after the lipid emulsion. The patient developed pancreatitis after the ILE therapy. This case is unique; not only is it one of the first reported cases of lipid emulsion being used in a pediatric patient, but in that the patient developed delayed toxicity and iatrogenic harm from the ILE.
近年来，静脉用脂肪乳剂（ILE）治疗作为一种新的解毒剂，已用于治疗某些毒性，包括环类抗抑郁药，并作为局部麻醉剂暴露后的主要治疗毒性表现。我们报告了一例 13 岁女孩，在摄入阿米替林后发生迟发性癫痫发作和心脏骤停。作为治疗的一部分，她接受了 ILE 治疗。患者的实验室在接受脂肪乳剂治疗数小时后无法解读。患者在接受 ILE 治疗后发生胰腺炎。这个病例很独特；不仅是首例报告在儿科患者中使用脂肪乳剂的病例之一，而且患者还发生了 ILE 引起的迟发性毒性和医源性损害。
