一匹美国花马因γ-氨基丁酸（GABA）生成减少引发的疑似“僵马综合征”病例。
Presumed case of "stiff-horse syndrome" caused by decreased gamma-aminobutyric acid (GABA) production in an American Paint mare.
作者信息
Purcell Tawna Backman, Sellers Ann Davidson, Goehring Lutz S
机构信息
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 300 West Drake Road, Fort Collins, Colorado 80523, USA.
出版信息
Can Vet J. 2012 Jan;53(1):75-8.
Abstract
Glutamic acid decarboxylase (GAD) converts glutamic acid into the inhibitory neurotransmitter γ-aminobutyric acid (GABA). Increased serum GAD (auto) antibody concentrations were found in a mare with increased postural musculature tone resulting in stiffness and recumbence. The mare was treated with dexamethasone which resulted in resolution of clinical signs and decreased GAD antibody concentrations.
摘要
谷氨酸脱羧酶（GAD）将谷氨酸转化为抑制性神经递质γ-氨基丁酸（GABA）。在一匹姿势性肌肉张力增加导致僵硬和卧地不起的母马中，发现血清GAD（自身）抗体浓度升高。该母马接受了地塞米松治疗，临床症状得到缓解，GAD抗体浓度降低。
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