van Galen G, Delguste C, Sandersen C, Verwilghen D, Grulke S, Amory H
Equine clinic, Faculty of Veterinary Medicine, University of Liege, Belgium.
Tijdschr Diergeneeskd. 2008 Jun 15;133(12):512-7.
Few studies exist about factors affecting the outcome of horses with tetanus.
31 equids (30 horses and 1 donkey) with a clinical diagnosis of tetanus admitted to the Equine Clinic of the University of Liege between 1991 and 2006. The cases were divided into two groups according to the outcome (survivors and non-survivors).
The clinical data of survivors and non-survivors were compared using an ANOVA (continuous data) or a Fisher's test (discrete data).
The survival rate was 32%. Most animals were 5 years or younger, and none had been appropriately vaccinated. The non-survivors were significantly younger than the survivors. The development of dyspnoea, recumbency, and the combination of dysphagia, dyspnoea, and recumbency was observed significantly more in the non-survivors than in the survivors. The timing of tetanus antitoxin administration (either immediately after the onset of suggestive signs or after a delay) was not different between the two groups. The time between the occurrence of a wound and the first signs ranged from 2 days to 2 months and was not significantly different between groups. All non-survivors died within 8 days of the first signs.
CONCLUSIONS & CLINICAL IMPORTANCE: This study suggests that young animals are affected more often and more severely by tetanus than older animals. Dyspnoea, recumbency, and the combination of dysphagia, dyspnoea, and recumbency can be considered as indicators of a poor prognosis in equids suffering from tetanus.
关于影响破伤风马匹预后因素的研究较少。
1991年至2006年间,31匹临床诊断为破伤风的马属动物(30匹马和1头驴)被收治于列日大学马科动物诊所。根据预后情况(存活和死亡)将病例分为两组。
采用方差分析(连续数据)或费舍尔检验(离散数据)比较存活组和死亡组的临床数据。
存活率为32%。大多数动物年龄在5岁及以下,且均未进行过适当的疫苗接种。死亡组动物明显比存活组动物年轻。与存活组相比,死亡组动物出现呼吸困难、卧地不起以及吞咽困难、呼吸困难和卧地不起同时出现的情况明显更多。两组在破伤风抗毒素给药时间(提示性症状出现后立即给药或延迟给药)上没有差异。伤口出现至首次出现症状的时间间隔为2天至2个月,两组间无显著差异。所有死亡动物均在首次出现症状后的8天内死亡。
本研究表明,幼年动物比成年动物更易感染破伤风且病情更严重。呼吸困难、卧地不起以及吞咽困难、呼吸困难和卧地不起同时出现可被视为破伤风马属动物预后不良的指标。