用 Ceriops decandra（Griff.）Ding Hou. 提取的红树林茶对二甲基苯并蒽诱导的仓鼠口腔颊囊癌唾液细菌菌群的影响。
Effect of Mangrove Tea Extract from Ceriops decandra (Griff.) Ding Hou. on Salivary Bacterial Flora of DMBA Induced Hamster Buccal Pouch Carcinoma.
出版信息
Indian J Microbiol. 2011 Jul;51(3):338-44. doi: 10.1007/s12088-011-0096-3. Epub 2011 Feb 27.
The objective of this study was to investigate the effects of mangrove tea on salivary bacterial flora in DMBA induced hamster buccal pouch carcinoma. Tea from mangrove plant Ceriops decandra was administered against DMBA induced buccal pouch carcinoma in hamster rats. The chemical constitutions and quality of mangrove tea is similar with the commercial tea Camellia sinensis. The Hamster rats were painted thrice a week with DMBA in their right buccal pouch, and also administrated orally with 1.25% of Ceriops tea extract, on alternate days of the DMBA treatment. Appropriate control animals were maintained. After 14 weeks of treatment, bacterial species in saliva were enumerated, tumor incidences were analyzed using histopathological section and tumor volume in the animals was quantified using water-displaced method. The decreased counts of beneficial bacteria and increased counts of harmful bacteria were associated with increased volume of tumors. The present study concluded that the tea extract from C. decandra prevents the oral cancer incidences and maintain the good health conditions of the animals.
本研究旨在探讨红树林茶对二甲基苯并蒽（DMBA）诱导的仓鼠颊囊癌变中唾液细菌菌群的影响。采用红树植物桐花树（Ceriops decandra）茶对仓鼠口腔颊囊癌变进行防治。红树林茶的化学组成和质量与市售茶叶——茶树（Camellia sinensis）相似。每周三次将 DMBA 涂抹于仓鼠右侧颊囊中，同时隔日口服 1.25%的桐花树茶提取物。对适当的对照动物进行维持。经过 14 周的治疗后，对唾液中的细菌种类进行计数，使用组织病理学切片分析肿瘤发生率，并使用排水法对动物的肿瘤体积进行定量。有益细菌数量减少和有害细菌数量增加与肿瘤体积增加有关。本研究得出结论，桐花树茶提取物可预防口腔癌的发生，维持动物的良好健康状态。
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