Liu Wen-Fang, Ji Shu-Rong, Sun Jian-Jun, Zhang Yi, Liu Zhong-Yan, Liang Ai-Bin, Zeng Hua-Zong
Department of General Surgery, Tongji Hospital of Tongji University, Shanghai 200065, China.
Central Laboratory, Tongji Hospital of Tongji University, Shanghai 200065, China.
Int J Mol Sci. 2012;13(5):6399-6406. doi: 10.3390/ijms13056399. Epub 2012 May 23.
CD146 has been regarded as a novel potential therapeutic target for multiple cancers. The aim of the study was to investigate the expression of CD146 in gastric cancer and evaluate its clinical-pathological and prognostic significance. The expression of CD146 and three epithelial-mesenchymal transition (EMT)-related proteins (E-cadherin, β-catenin and vimentin) was examined in 144 gastric cancers by immunohistochemistry. Fifty-nine cases (41.0%) were defined as positive for CD146 expression. We found that CD146 expression correlated positively with lymph node involvement and a poor prognosis, and retained an independent prognostic factor for gastric cancer patients. Furthermore, positive expression of CD146 was strongly associated with loss of the epithelial marker E-cadherin and acquisition of the expression of the mesenchymal markers nuclear β-catenin and vimentin. These findings suggest that CD146 might promote EMT and progression in gastric cancer, and thus may be a potential therapeutic target for patients with gastric cancers.
CD146被视为多种癌症的一种新型潜在治疗靶点。本研究旨在调查CD146在胃癌中的表达情况，并评估其临床病理及预后意义。采用免疫组织化学方法检测了144例胃癌组织中CD146及三种上皮-间质转化（EMT）相关蛋白（E-钙黏蛋白、β-连环蛋白和波形蛋白）的表达。59例（41.0%）被定义为CD146表达阳性。我们发现CD146表达与淋巴结转移及不良预后呈正相关，并且是胃癌患者的一个独立预后因素。此外，CD146的阳性表达与上皮标志物E-钙黏蛋白的缺失以及间质标志物核β-连环蛋白和波形蛋白表达的获得密切相关。这些发现提示CD146可能促进胃癌中的EMT及进展，因此可能是胃癌患者的一个潜在治疗靶点。
