Jimenez-Estrada Manuel, Merino-Aguilar Hector, Lopez-Fernandez Adriana, Rojano-Vilchis Nadia A, Roman-Ramos Ruben, Alarcon-Aguilar Francisco Javier
Universidad Nacional Autonoma de Mexico.
J Complement Integr Med. 2011 Jan;8. doi: 10.2202/1553-3840.1413.
Psacalium decompositum (Gray) H.E. Rob. & Brett (Asteraceae), popularly known as "matarique," is a medicinal plant used in Mexico for the empirical treatment of diabetes mellitus. Previous studies with P. decompositum roots demonstrated that an aqueous fraction containing carbohydrates (WMP-fraction) exhibited a notable hypoglycemic effect in experimental animals. However, studies to identify these carbohydrates have not yet been performed. The goal of this investigation was to isolate and characterize the principal compounds in the WMP-fraction by spectroscopic and spectrometric analysis. Additionally, we sought to evaluate the hypoglycemic effect of these compounds in healthy and alloxan-induced diabetic mice. The results show that the chemical structures of the major compounds in the WMP-fraction correspond with fructan-type oligosaccharides and have a hypoglycemic effect in healthy and diabetic mice.
墨西哥假泽兰（Psacalium decompositum (Gray) H.E. Rob. & Brett，菊科），俗称“马塔里基”，是一种在墨西哥用于经验性治疗糖尿病的药用植物。先前对墨西哥假泽兰根部的研究表明，含有碳水化合物的水相部分（WMP部分）在实验动物中表现出显著的降血糖作用。然而，尚未开展鉴定这些碳水化合物的研究。本研究的目的是通过光谱和光谱分析分离并表征WMP部分中的主要化合物。此外，我们试图评估这些化合物对健康小鼠和四氧嘧啶诱导的糖尿病小鼠降糖作用。结果表明，WMP部分中主要化合物的化学结构与果聚糖型低聚糖相符，并且对健康小鼠和糖尿病小鼠均有降血糖作用。
