Departments of Biochemistry Dermatology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
J Eur Acad Dermatol Venereol. 2013 Mar;27(3):e289-93. doi: 10.1111/j.1468-3083.2012.04631.x. Epub 2012 Jul 3.
Behçet's disease (BD) is a chronic multisystem inflammatory disorder characterized by vasculitis. Vasculitis is thought to underlie many of the clinical manifestations of Behçet's disease. Lipoprotein-associated phospholipase A2 (Lp-PLA2 ) is a highly specific biomarker for vascular inflammation, and has low biological variability. Those features make it more attractive than other inflammatory markers including C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), which may reflect systemic inflammation non-specifically.
It was aimed to investigate circulating Lp-PLA2 levels and its relationship with CRP and ESR in patients with BD by considering disease activity.
Study group included 72 patients with BD (34 men and 38 women with a mean age of 35.3 years) and 30 sex- and age-matched healthy subjects (15 men and 15 women with a mean age 32.6 years). Patients group included 40 patients with active and 32 patients with inactive BD.
Lp-PLA2 , CRP and ESR levels were found to be significantly higher in patient group than controls. In addition, those levels were also significantly higher in patients with active BD than in patients with inactive disease. Lp-PLA2 showed positive correlations with CRP and ESR (r = 0.63, P < 0.05 and r = 0.33, P < 0.05 respectively). Lp-PLA2 also showed significant important area under curve (AUC) value (0.779), besides CRP (0.941) and ESR (0.888). Optimum cut-off value was obtained as 218.5 ng/mL.
It was concluded that Lp-PLA2 may be a new useful biomarker to evaluate clinical or subclinical activity of the disease besides CRP and ESR.
白塞病（BD）是一种以血管炎为特征的慢性多系统炎症性疾病。血管炎被认为是白塞病许多临床表现的基础。脂蛋白相关磷脂酶 A2（Lp-PLA2）是血管炎症的高度特异性生物标志物，且具有较低的生物学变异性。这些特征使其比其他炎症标志物（包括 C 反应蛋白（CRP）和红细胞沉降率（ESR））更具吸引力，因为后者可能非特异性地反映全身炎症。
通过考虑疾病活动度，旨在研究白塞病患者循环 Lp-PLA2 水平及其与 CRP 和 ESR 的关系。
研究组包括 72 例白塞病患者（34 名男性和 38 名女性，平均年龄为 35.3 岁）和 30 名性别和年龄匹配的健康对照者（15 名男性和 15 名女性，平均年龄 32.6 岁）。患者组包括 40 例活动期和 32 例缓解期白塞病患者。
与对照组相比，患者组的 Lp-PLA2、CRP 和 ESR 水平均显著升高。此外，活动期白塞病患者的这些水平也明显高于缓解期患者。Lp-PLA2 与 CRP 和 ESR 呈正相关（r = 0.63，P < 0.05 和 r = 0.33，P < 0.05）。Lp-PLA2 还具有显著重要的曲线下面积（AUC）值（0.779），此外 CRP（0.941）和 ESR（0.888）也具有显著重要的 AUC 值。最佳截断值为 218.5ng/mL。
Lp-PLA2 可能是一种除 CRP 和 ESR 之外评估疾病临床或亚临床活动的新的有用生物标志物。
