Karapetian A T, Vardevanian P O, Frank-Kamenetskii M D
Kirovakan Teachers Training Institute, Armenian SSR, USSR.
J Biomol Struct Dyn. 1990 Aug;8(1):131-8. doi: 10.1080/07391102.1990.10507794.
The enthalpy of helix-coil transition of DNA (delta H) is determined from the experiments on DNA melting with ligands by means of absolutely general formula, which contains only values directly known from the experiment (M.D. Frank-Kamenetskii, and A.T. Karapetian, Mol. Biol. USSR 6, 621 (1972)) with the combination of the "area" method (P.O. Vardevanian, et al., Biophysica 28, 130 (1983)). The experimentally obtained data show that delta H depends on both concentration of Na+ in solution and GC-content of DNA and is of high accuracy.
通过“面积”法（P.O. 瓦尔代瓦尼安等人，《生物物理学》28，130（1983））与仅包含实验中直接已知值的绝对通用公式（M.D. 弗兰克 - 卡缅涅茨基和A.T. 卡拉佩季安，《苏联分子生物学》6，621（1972））相结合，根据DNA与配体熔解实验确定了DNA螺旋 - 卷曲转变的焓（ΔH）。实验获得的数据表明，ΔH既取决于溶液中Na⁺的浓度，也取决于DNA的GC含量，并且具有很高的准确性。
