Karczewski Marek, Rzymski Piotr, Karczewski Jacek
Poznan University of Medical Sciences, Fredry 10, 60-701 Poznan, Poland.
Exp Clin Transplant. 2012 Aug;10(4):310-3. doi: 10.6002/ect.2011.0194. Epub 2012 Jul 3.
Our study aimed to determine the incidence of de novo renal cell carcinoma in the native kidneys of patients transplanted at our center and to identify possible risk factors.
We performed a retrospective, single-center cohort study, which included patients transplanted at the District Hospital in Poznan, Poland, during 1994-2011, among whom 836 were selected. Sixty-three patients with confirmed de novo cancer were found. Of those, 11 had renal cell carcinoma in the native kidney (1.3%) and 2 in the transplanted kidney (0.2%).
Mean follow-up was 10 ± 3.2 years. Mean age at renal cell carcinoma diagnosis was 52 ± 9.4 years, and mean time from transplant was 3 ± 2.6 years. A statistical analysis showed no significant differences in demographic or clinical characteristics between renal cell carcinoma and noncancer group, except for the prevalence of male sex and smoking in the cancer group (P < .05).
Renal cell carcinoma development in the native kidney seems to be an early event, frequently observed within 4 to 5 years after transplant. We believe that kidneys in renal transplant recipients should be routinely screened by ultrasound for early diagnosis.
我们的研究旨在确定在我们中心接受移植患者的原生肾中新生肾细胞癌的发病率，并确定可能的危险因素。
我们进行了一项回顾性单中心队列研究，纳入了1994年至2011年期间在波兰波兹南地区医院接受移植的患者，从中选取了836例。发现63例确诊为新生癌症的患者。其中，11例在原生肾中发生肾细胞癌（1.3%），2例在移植肾中发生肾细胞癌（0.2%）。
平均随访时间为10±3.2年。肾细胞癌诊断时的平均年龄为52±9.4岁，移植后的平均时间为3±2.6年。统计分析显示，肾细胞癌组和非癌症组在人口统计学或临床特征方面无显著差异，但癌症组中男性和吸烟的患病率除外（P<.05）。
原生肾中肾细胞癌的发生似乎是一个早期事件，常在移植后4至5年内出现。我们认为，肾移植受者的肾脏应定期进行超声筛查以早期诊断。
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