Doublet J D, Peraldi M N, Gattegno B, Thibault P, Sraer J D
Department of Urology, Tenon Hospital, Paris, France.
J Urol. 1997 Jul;158(1):42-4. doi: 10.1097/00005392-199707000-00012.
We evaluated the prevalence of renal cell carcinoma of the native kidneys in renal transplant recipients as well as possible risk factors.
A total of 129 consecutive renal transplant recipients underwent ultrasound examination of the native kidneys as part of a routine evaluation. A record was made of acquired cystic kidney disease, defined as 3 cysts or more, and of suspicious masses. When a malignancy was suspected radical nephrectomy was performed.
The overall prevalence of renal cell carcinoma of the native kidney was 5 in 129 recipients (3.9%). All cancers were limited to the kidney. No significant relationship was detected between renal cell carcinoma occurrence and patient age, dialysis (when initiated, type and duration), transplantation, drug regimen or incidence of acquired cystic kidney disease.
The risk of renal cell carcinoma, a clinically significant cancer, was approximately 100 times greater in our renal transplant patients than in the general population but no significant risk factor could be identified. Routine ultrasonography for early diagnosis in asymptomatic patients on immunosuppressive therapy is strongly recommended to improve prognosis.
我们评估了肾移植受者中天然肾肾细胞癌的患病率以及可能的危险因素。
总共129例连续的肾移植受者接受了天然肾超声检查，作为常规评估的一部分。记录获得性肾囊肿病（定义为3个或更多囊肿）和可疑肿块情况。当怀疑为恶性肿瘤时，进行根治性肾切除术。
129例受者中天然肾肾细胞癌的总体患病率为5例（3.9%）。所有癌症均局限于肾脏。未发现肾细胞癌的发生与患者年龄、透析（开始时间、类型和持续时间）、移植、药物治疗方案或获得性肾囊肿病的发生率之间存在显著关系。
在我们的肾移植患者中，具有临床意义的癌症——肾细胞癌的风险比普通人群高约100倍，但未发现显著的危险因素。强烈建议对接受免疫抑制治疗的无症状患者进行常规超声检查以早期诊断，从而改善预后。
