Abdelwahid Eltyeb, Siminiak Tomasz, Guarita-Souza Luiz Cesar, Teixeira de Carvalho Katherine Athayde, Gallo Pasquale, Shim Winston, Condorelli Gianluigi
CBRC, Massachusetts General Hospital/Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Curr Cardiol Rev. 2011 Aug;7(3):201-12. doi: 10.2174/157340311798220502.
Degeneration of cardiac tissues is considered a major cause of mortality in the western world and is expected to be a greater problem in the forthcoming decades. Cardiac damage is associated with dysfunction and irreversible loss of cardiomyocytes. Stem cell therapy for ischemic heart failure is very promising approach in cardiovascular medicine. Initial trials have indicated the ability of cardiomyocytes to regenerate after myocardial injury. These preliminary trials aim to translate cardiac regeneration strategies into clinical practice. In spite of advances, current therapeutic strategies to ischemic heart failure remain very limited. Moreover, major obstacles still need to be solved before stem cell therapy can be fully applied. This review addresses the current state of research and experimental data regarding embryonic stem cells (ESCs), myoblast transplantation, histological and functional analysis of transplantation of co-cultured myoblasts and mesenchymal stem cells, as well as comparison between mononuclear and mesenchymal stem cells in a model of myocardium infarction. We also discuss how research with stem cell transplantation could translate to improvement of cardiac function.
心脏组织的退化被认为是西方世界死亡的主要原因，并且预计在未来几十年将成为一个更严重的问题。心脏损伤与心肌细胞功能障碍和不可逆损失有关。缺血性心力衰竭的干细胞治疗是心血管医学中非常有前景的方法。初步试验表明心肌损伤后心肌细胞具有再生能力。这些初步试验旨在将心脏再生策略转化为临床实践。尽管取得了进展，但目前针对缺血性心力衰竭的治疗策略仍然非常有限。此外，在干细胞治疗能够全面应用之前，仍有一些主要障碍需要解决。本综述阐述了关于胚胎干细胞（ESC）、成肌细胞移植、共培养成肌细胞与间充质干细胞移植的组织学和功能分析，以及心肌梗死模型中单核细胞与间充质干细胞比较的研究现状和实验数据。我们还讨论了干细胞移植研究如何能够转化为心脏功能的改善。
