简要综述：骨髓间充质干细胞在心肌梗死中的治疗潜力。
A brief review: the therapeutic potential of bone marrow mesenchymal stem cells in myocardial infarction.
机构信息
Cardiovascular Department Of Internal Medicine, The Fourth Affiliated Hospital of China Medical University, Chongshandong Street No.4, Shenyang, 110032, China.
出版信息
Stem Cell Res Ther. 2017 Nov 2;8(1):242. doi: 10.1186/s13287-017-0697-9.
Abstract
Myocardial infarction (MI) results in dysfunction and irreversible loss of cardiomyocytes and is among the most serious health threats today. Bone marrow mesenchymal stem cells (BMSCs), with their capacity for multidirectional differentiation, low immunogenicity, and high portability, can serve as ideal seed cells in cardiovascular disease therapy. In this review, we examine recent literature concerning the application of BMSCs for the treatment of MI and consider the following aspects: activity of transplanted cells, migration and homing of BMSCs, immunomodulatory and anti-inflammatory effects of BMSCs, anti-fibrotic activity of BMSCs, the role of BMSCs in angiogenesis, and differentiation of BMSCs into cardiomyocyte-like cells and endothelial cells. Each aspect is complementary to the others and together they promote the repair of cardiomyocytes by BMSCs after MI. Although transplantation of BMSCs has enabled new options for MI treatment, the critical issue we must now address is the reduced viability of transplanted BMSCs due to inadequate blood supply, poor nourishment of cells, and generation of free radicals. More clinical trials are needed to prove the therapeutic potential of BMSCs in MI.
摘要
心肌梗死（MI）导致心肌细胞功能障碍和不可逆转的损失，是当今最严重的健康威胁之一。骨髓间充质干细胞（BMSCs）具有多向分化能力、低免疫原性和高可移植性，可作为心血管疾病治疗的理想种子细胞。在这篇综述中，我们研究了关于 BMSCs 治疗 MI 的最新文献，并考虑了以下几个方面：移植细胞的活性、BMSCs 的迁移和归巢、BMSCs 的免疫调节和抗炎作用、BMSCs 的抗纤维化作用、BMSCs 在血管生成中的作用以及 BMSCs 向心肌细胞样细胞和内皮细胞的分化。每个方面都是相互补充的，共同促进了 BMSCs 在 MI 后对心肌细胞的修复。尽管 BMSCs 的移植为 MI 的治疗提供了新的选择，但我们现在必须解决的关键问题是由于血液供应不足、细胞营养不足和自由基的产生，导致移植的 BMSCs 活力降低。需要更多的临床试验来证明 BMSCs 在 MI 中的治疗潜力。
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