Volkova Maria, Russell Raymond
Section of Cardiovascular Medicine, Yale University School of Medicine, USA.
Curr Cardiol Rev. 2011 Nov;7(4):214-20. doi: 10.2174/157340311799960645.
Anthracyclines, such as doxorubicin and idarubicin, remain an important class of chemotherapeutic agents. Unfortunately, their efficacy in treating cancer is limited by a cumulative dose-dependent cardiotoxicity, which can cause irreversible heart failure. In this review, we discuss the pathogenesis and incidence of anthracycline-induced cardiotoxicity as well as methods to detect, prevent and treat the condition.
蒽环类药物，如多柔比星和伊达比星，仍然是一类重要的化疗药物。不幸的是，它们在治疗癌症方面的疗效受到累积剂量依赖性心脏毒性的限制，这种毒性可导致不可逆的心力衰竭。在这篇综述中，我们讨论了蒽环类药物诱导的心脏毒性的发病机制和发生率，以及检测、预防和治疗这种病症的方法。
