Department of Anatomy and Cell Biology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Ann N Y Acad Sci. 2012 Jul;1259:47-53. doi: 10.1111/j.1749-6632.2012.06532.x.
Sarcopenia, the age-related loss of muscle mass and strength, is a multifactorial impaired state of health. Lifestyle habits such as physical activity and nutrition have a major impact on sarcopenia progression. Several epidemiological studies have also shown an association between cigarette smoking and increased levels of sarcopenia in elderly long-time smokers. Clinical, in vivo, and in vitro studies have tried to investigate the mechanism behind exposure to cigarette smoke (CS) and the subsequent effects on skeletal muscles. The aim of this review is to present a cellular model of CS-induced skeletal muscle protein breakdown based on recent studies dealing with this issue and to propose new potential research directions that may explain the effects of exposure to CS on skeletal muscle integrity.
肌肉减少症是一种与年龄相关的肌肉质量和力量损失，是一种多因素的健康受损状态。生活方式习惯，如体育活动和营养，对肌肉减少症的进展有重大影响。几项流行病学研究还表明，吸烟与老年长期吸烟者肌肉减少症水平升高之间存在关联。临床、体内和体外研究试图探究接触香烟烟雾（CS）的背后机制以及对骨骼肌的后续影响。本综述的目的是基于最近研究提出一个 CS 诱导的骨骼肌蛋白分解的细胞模型，并提出可能解释 CS 对骨骼肌完整性影响的新的潜在研究方向。
