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内镜下球囊扩张术治疗克罗恩病所致胃肠道狭窄是可行的。

Endoscopic balloon dilatation for Crohn's strictures of the gastrointestinal tract is feasible.

作者信息

Karstensen John Gásdal, Hendel Jakob, Vilmann Peter

机构信息

Department of Surgical Gastroenterology, Hvidovre Hospital, Hvidovre, Denmark.

出版信息

Dan Med J. 2012 Jul;59(7):A4471.

Abstract

INTRODUCTION

Despite optimized medical treatment, Crohn´s disease can cause gastrointestinal (GI) strictures, which requires surgical intervention. Lately, endoscopic balloon dilatation has been established as an alternative to surgery. In the following, we report our experiences with endoscopic dilatation of strictures in the gastrointestinal tract caused by Crohn´s disease.

MATERIAL AND METHODS

From January 2005 to February 2011, 23 patients with Crohn´s disease were referred for endoscopic dilatation. Based on data derived from this cohort, a retrospective analysis was made. Patients with Crohn´s disease, obstructive GI symptoms and known bowel strictures were included. Their mean age was 39 years (20-59 years) and 65% were female. Prior to the procedure, all patients had been evaluated by barium small-bowel follow through, abdominal magnetic resonance imaging and/or endoscopy.

RESULTS

Dilatation was performed in 19/23 (83%) patients. During a mean follow-up period of 21 months (range 1-47 months), relapse was observed in 14/19 patients (74%). Five patients (26%) were referred to surgery due to complications (n = 1) or multiple relapses (n = 4). A total of 54 endoscopic dilatations were performed during the study period. Only one complication (perforation) was experienced, which resulted in a complication rate of 1.9%.

CONCLUSION

Endoscopic dilatation in patients with Crohn´s disease with obstructive GI symptoms seems safe. In three out of four patients, surgery was avoided during a mean follow-up of two years. Further optimisation of the procedure is needed to lower the rate of recurrence.

摘要

引言

尽管进行了优化的药物治疗,克罗恩病仍可导致胃肠道狭窄,这需要手术干预。近来,内镜下球囊扩张已被确立为手术的替代方法。在此,我们报告我们对克罗恩病所致胃肠道狭窄进行内镜扩张的经验。

材料与方法

2005年1月至2011年2月,23例克罗恩病患者被转诊接受内镜扩张治疗。基于该队列获得的数据进行回顾性分析。纳入患有克罗恩病、有阻塞性胃肠道症状且已知肠道狭窄的患者。他们的平均年龄为39岁(20 - 59岁),65%为女性。在手术前,所有患者均接受了钡剂小肠造影、腹部磁共振成像和/或内镜检查评估。

结果

19/23(83%)例患者接受了扩张治疗。在平均21个月(范围1 - 47个月)的随访期内,14/19(74%)例患者出现复发。5例患者(26%)因并发症(n = 1)或多次复发(n = 4)而接受手术治疗。在研究期间共进行了54次内镜扩张。仅发生1例并发症(穿孔),并发症发生率为1.9%。

结论

对有阻塞性胃肠道症状的克罗恩病患者进行内镜扩张似乎是安全的。在平均两年的随访期内,四分之三的患者避免了手术。需要进一步优化该操作以降低复发率。

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