Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan.
Peptides. 2012 Sep;37(1):13-7. doi: 10.1016/j.peptides.2012.06.015. Epub 2012 Jul 1.
Broiler chicks eat more food than layer chicks. However, the causes of the difference in food intake in the neonatal period between these strains are not clear. In this study, we examined the involvement of proopiomelanocortin (POMC)-derived melanocortin peptides α-, β- and γ-melanocyte-stimulating hormones (MSHs) in the difference in food intake between broiler and layer chicks. First, we compared the hypothalamic mRNA levels of POMC between these strains and found that there was no significant difference in these levels between broiler and layer chicks. Next, we examined the effects of central administration of MSHs on food intake in these strains. Central administration of α-MSH significantly suppressed food intake in both strains. Central administration of β-MSH significantly suppressed food intake in layer chicks, but not in broiler chicks, while central administration of γ-MSH did not influence food intake in either strain. It is therefore likely that the absence of the anorexigenic effect of β-MSH might be related to the increased food intake in broiler chicks.
肉鸡雏鸡比蛋鸡雏鸡吃更多的食物。然而，这些品种在新生儿期食物摄入量差异的原因尚不清楚。在这项研究中，我们研究了促黑激素细胞刺激素（MSH）α、β和γ在肉鸡和蛋鸡雏鸡食物摄入量差异中的作用。首先，我们比较了这两种鸡的下丘脑 POMC 基因的 mRNA 水平，发现两者之间没有显著差异。接下来，我们研究了 MSH 对这两种鸡摄食的中枢作用。α-MSH 的中枢给药显著抑制了两种鸡的摄食。β-MSH 的中枢给药显著抑制了蛋鸡的摄食，但对肉鸡没有影响，而 γ-MSH 的中枢给药对两种鸡的摄食都没有影响。因此，β-MSH 的厌食作用的缺失可能与肉鸡摄食增加有关。
