Keller K, Beule J, Scholz M, Pfnür M, Dippold W
II. Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz.
Z Gastroenterol. 2012 Jul;50(7):694-8. doi: 10.1055/s-0031-1299502. Epub 2012 Jul 3.
CVS (cyclic vomiting syndrome) is a functional disorder that can occur in all age groups. Adults typically develop CVS in middle age (around the 35th year of life). CVS is characterised by recurrent stereotypic episodes of nausea and vomiting lasting hours or some days. Between these episodes there are intervals free of symptoms. The main symptoms include nausea, vomiting and often abdominal pain. CVS is a rare disorder in adult patients. Because of the lack of awarness, making the correct diagnosis is not easy und often delayed for some months or years. There is no specific test to secure the diagnosis. The accurate diagnosis is based on the typical anamnestic report and the exclusion of other disorders associated with a recurrent vomiting. No standard evidence-based treatment is currently available either to manage the acute vomiting episode or to manage the prophylactic therapy. For the acute treatment of the vomiting episodes antiemetic, antimigraine and sedative medications were used. The medications frequently used for the prophylactic therapy are amitriptyline and propranolol.
周期性呕吐综合征（CVS）是一种可发生于所有年龄组的功能性疾病。成年人通常在中年（约35岁）时患上CVS。CVS的特征是反复出现刻板性的恶心和呕吐发作，持续数小时或数天。在这些发作之间有无症状的间歇期。主要症状包括恶心、呕吐，常伴有腹痛。CVS在成年患者中是一种罕见疾病。由于认识不足，做出正确诊断并不容易，且常常延迟数月或数年。没有用于确诊的特异性检查。准确的诊断基于典型的病史报告以及排除与反复呕吐相关的其他疾病。目前也没有用于管理急性呕吐发作或预防性治疗的标准循证治疗方法。对于呕吐发作的急性治疗，使用了止吐药、抗偏头痛药和镇静药。预防性治疗常用的药物是阿米替林和普萘洛尔。
