Mater Dei Hospital, 17, Floreat, Triq il-Kbira, Gharghur, Malta (EU).
Ther Adv Respir Dis. 2012 Aug;6(4):243-6. doi: 10.1177/1753465812452192. Epub 2012 Jul 3.
Statins are widely used for primary and secondary prevention of cardiovascular disease. For this reason, knowledge of the side effects and interactions pertaining to this class of pharmaceuticals is of utmost importance to all physicians. In this text a case report is presented of an eighty year old gentleman, referred to the respiratory clinic at Mater Dei Hospital Malta after developing dry cough on being treated with simvastatin and fluvastatin. An attempt at switching over to a placebo was made with resolution of symptoms. This is the second described case in the literature of lone cough associated with statin therapy necessitating treatment discontinuation in our patient. Possible hypothesis are discussed as well as suggestions for further research to unravel the underlying mechanisms of this association.
他汀类药物广泛用于心血管疾病的一级和二级预防。出于这个原因，了解与这类药物相关的副作用和相互作用对所有医生来说都是至关重要的。在本文中，我们报告了一个 80 岁男性的病例，他在使用辛伐他汀和氟伐他汀治疗后出现干咳，被转到马耳他玛特代尔医院的呼吸科就诊。尝试用安慰剂治疗，症状得到缓解。这是文献中描述的第二例与他汀类药物治疗相关的孤立性咳嗽病例，导致我们的患者停止治疗。还讨论了可能的假说，并提出了进一步研究的建议，以揭示这种关联的潜在机制。
