H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612-9416, USA.
Cancer Epidemiol Biomarkers Prev. 2012 Sep;21(9):1542-6. doi: 10.1158/1055-9965.EPI-12-0483. Epub 2012 Jul 3.
It is largely unknown if antihuman papillomavirus (HPV) serum antibody responses vary by anatomic site of infection in men.
This study assessed type-specific anti-HPV serum antibody prevalence associated with corresponding HPV DNA detection in the external genitalia and the anal canal of 1,587 heterosexual men and 199 men who have sex with men (MSM).
We observed that HPV 6 and 16 seroprevalence was higher in the presence of same HPV-type infection in the anal canal compared with same HPV-type infection in the external genitalia only, and among MSM compared with the heterosexual men. Seropositivity to HPV 6 was strongly associated with HPV 6 DNA detection in the anal canal but not in the external genitalia alone among both heterosexual men [adjusted prevalence ratio (APR), anal+/genital+ vs. anal-/genital-: 4.2, 95% confidence interval (CI), 11.7-10.5; anal+/genital- vs. anal-/genital-: 7.9 (95% CI, 3.7-17.0)] and MSM [APR, anal+/genital+ vs. anal-/genital-: 5.6 (95% CI, 2.7-11.9); anal+/genital- vs. anal-/genital-: 3.2 (95% CI, 2.1-4.9)]. Similar associations between seropositivity to HPV 16 and anal HPV 16 DNA detection were only observed in MSM [anal+/genital+ vs. anal-/genital-: 3.1 (95% CI, 2.0-5.0); anal+/genital- vs. anal-/genital-: 2.2 (95% CI, 1.3-3.5)].
Our data showed that seroprevalence varied by anatomic site of HPV infection, suggesting differences in epithelium type present at these anatomic sites may be relevant.
Our finding is instrumental in advancing our understanding of immune mechanism involved in anatomic site-specific antibody response.
目前尚不清楚男性的 HPV 血清抗体反应是否因感染的解剖部位而异。
本研究评估了在 1587 名异性恋男性和 199 名男男性接触者（MSM）的外生殖器和肛门部位，与相应 HPV DNA 检测相关的 HPV 血清型特异性抗 HPV 抗体的流行率。
我们观察到，与仅在外生殖器存在相同 HPV 型感染相比，在肛门部位存在相同 HPV 型感染时，HPV 6 和 16 的血清阳性率更高，而且在 MSM 中高于异性恋男性。HPV 6 的血清阳性与肛门部位的 HPV 6 DNA 检测呈强相关，但在外生殖器单独存在时无此关联，在异性恋男性中[调整后的流行率比（APR），肛门+/生殖器+与肛门-/生殖器-：4.2，95%置信区间（CI），11.7-10.5；肛门+/生殖器-与肛门-/生殖器-：7.9（95% CI，3.7-17.0）]和 MSM [APR，肛门+/生殖器+与肛门-/生殖器-：5.6（95% CI，2.7-11.9）；肛门+/生殖器-与肛门-/生殖器-：3.2（95% CI，2.1-4.9）]。仅在 MSM 中观察到 HPV 16 血清阳性与肛门 HPV 16 DNA 检测之间存在类似的关联[肛门+/生殖器+与肛门-/生殖器-：3.1（95% CI，2.0-5.0）；肛门+/生殖器-与肛门-/生殖器-：2.2（95% CI，1.3-3.5）]。
我们的数据表明，血清阳性率因 HPV 感染的解剖部位而异，这表明这些解剖部位上皮类型的差异可能是相关的。
我们的发现有助于深入了解与解剖部位特异性抗体反应相关的免疫机制。
