University of Washington HPV Research Group, Box 359933, 325 9th Avenue, Seattle, WA 98104, USA.
Cancer Epidemiol Biomarkers Prev. 2010 Jul;19(7):1682-5. doi: 10.1158/1055-9965.EPI-10-0226. Epub 2010 Jun 22.
Little is known about detection of genital human papilloma virus (HPV) types in women's fingertips. The study objectives were to determine the presence of genital HPV types in fingertip samples and the agreement between fingertip and genital samples for detecting HPV.
At triannual visits, genital and fingertip samples were collected from female university students and tested for 37 HPV genotypes by PCR-based assay. Type-specific concordance between paired fingertip and genital samples was evaluated using kappa statistics for percent positive agreement (kappa+). Paired samples with type-specific concordant fingertip and genital results were selected for variant characterization.
A total of 357 fingertip samples were collected from 128 women. HPV prevalence in fingertip samples was 14.3%. Although percent positive agreement between fingertips and genitals for detecting type-specific HPV was low (17.8%; kappa+ = 0.17; 95% confidence interval, 0.10-0.25), 60.4% of type-specific HPV detected in the fingertips was detected in a concurrent genital sample. All but one of 28 paired concordant samples were positive for the same type-specific variant in the fingertip and genital sample. Redetection of HPV types at the subsequent visit was more common in genital samples (73.3%) than in fingertip samples (14.5%; P < 0.001).
Detection of genital HPV types in the fingertips was not uncommon. Although impossible to distinguish between deposition of DNA from the genitals to the fingertips and true fingertip infection, the rarity of repeat detection in the fingertips suggests that deposition is more common.
Finger-genital transmission is plausible but unlikely to be a significant source of genital HPV infection.
目前对于女性指尖是否存在生殖器人乳头瘤病毒（HPV）类型知之甚少。本研究旨在确定指尖样本中是否存在生殖器 HPV 类型，以及指尖和生殖器样本检测 HPV 的一致性。
在每三年一次的访问中，从女大学生的生殖器和指尖采集样本，并通过基于 PCR 的检测方法检测 37 种 HPV 基因型。使用阳性一致性的kappa 统计量（kappa+）评估指尖和生殖器配对样本的 HPV 型别一致性。选择具有特定型别一致性的指尖和生殖器结果的配对样本进行变异特征分析。
共采集了 128 名女性的 357 个指尖样本。指尖样本的 HPV 流行率为 14.3%。尽管指尖和生殖器检测特定型别 HPV 的阳性一致性百分比较低（17.8%；kappa+ = 0.17；95%置信区间，0.10-0.25），但在指尖样本中检测到的 60.4%特定型别 HPV 也在同时采集的生殖器样本中检测到。28 对配对一致样本中，除了 1 对，其余均在指尖和生殖器样本中检测到相同的特定型别变异。在随后的访问中，HPV 类型在生殖器样本中的再检出率（73.3%）高于指尖样本（14.5%；P < 0.001）。
在指尖检测到生殖器 HPV 类型并不罕见。虽然无法区分是生殖器 DNA 沉积到指尖还是真正的指尖感染，但在指尖中重复检测的罕见性表明，沉积更为常见。
手指-生殖器传播是合理的，但不太可能成为生殖器 HPV 感染的主要来源。
