神经细胞黏附分子 4 是犬瘟热病毒的上皮细胞受体，参与病毒的神经毒力。
Nectin4 is an epithelial cell receptor for canine distemper virus and involved in neurovirulence.
机构信息
Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
出版信息
J Virol. 2012 Sep;86(18):10207-10. doi: 10.1128/JVI.00824-12. Epub 2012 Jul 3.
Abstract
Canine distemper virus (CDV) uses signaling lymphocyte activation molecule (SLAM), expressed on immune cells, as a receptor. However, epithelial and neural cells are also affected by CDV in vivo. Wild-type CDV strains showed efficient replication with syncytia in Vero cells expressing dog nectin4, and the infection was blocked by an anti-nectin4 antibody. In dogs with distemper, CDV antigen was preferentially detected in nectin4-positive neurons and epithelial cells, suggesting that nectin4 is an epithelial cell receptor for CDV and also involved in its neurovirulence.
摘要
犬瘟热病毒 (CDV) 使用信号淋巴细胞激活分子 (SLAM) 作为受体，而 SLAM 表达于免疫细胞上。然而，在体内，上皮细胞和神经细胞也会受到 CDV 的影响。野生型 CDV 株在表达犬 nectin4 的 Vero 细胞中显示出有效的复制和融合，并且感染可以被抗 nectin4 抗体阻断。在患有犬瘟热的犬中，CDV 抗原优先在 nectin4 阳性神经元和上皮细胞中被检测到，这表明 nectin4 是 CDV 的上皮细胞受体，并且也参与其神经毒力。
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