Ando Takashi, Ishikawa Takeshi, Imamoto Eiko, Kishimoto Etsuko, Suzuki Kentaro, Isozaki Yutaka, Matsumoto Naoyuki, Oyamada Hirokazu, Matsumoto Tsuguhiro, Uchiyama Kazuhiko, Handa Osamu, Takagi Tomohisa, Yagi Nobuaki, Kokura Satoshi, Naito Yuji, Yoshikawa Toshikazu
Department of Gastroenterology, Social Insurance Kyoto Hospital, Kyoto Prefectural University of Medicine, Kyoto, Moriguchi, Japan.
Case Rep Gastroenterol. 2012 Jan;6(1):111-7. doi: 10.1159/000336821. Epub 2012 Feb 18.
A 50-year-old female became aware of skin yellowing and consulted another hospital where she was diagnosed intraoperatively with duodenal cancer because of lymph node metastases around the aorta. Endoscopy revealed type IIa + IIc cancer distal to the duodenal papilla, and biopsy allowed a diagnosis of well-differentiated adenocarcinoma. Computed tomography revealed a large number of lymph node metastases around the aorta and in the left supraclavicular cavity. The patient was given many regimens of chemotherapy, mainly containing S-1, and multidisciplinary treatment, and achieved long-term survival for 6 years and 1 month. This is a valuable case suggesting the usefulness of this therapeutic approach. In view of the fact that duodenal cancer is a relatively rare disease and the possibility that the incidence of this disease may increase in the future, it seems essential to collect additional data from multicenter prospective studies towards the goal of establishing a standard method of treatment for this disease.
一名50岁女性发现皮肤发黄，遂前往另一家医院就诊，术中因主动脉周围淋巴结转移被诊断为十二指肠癌。内镜检查显示十二指肠乳头远端为IIa + IIc型癌，活检确诊为高分化腺癌。计算机断层扫描显示主动脉周围和左锁骨上腔有大量淋巴结转移。该患者接受了多种主要含S-1的化疗方案及多学科治疗，实现了6年1个月的长期生存。这是一个有价值的病例，提示了这种治疗方法的有效性。鉴于十二指肠癌是一种相对罕见的疾病，且未来该病发病率可能增加，似乎有必要从多中心前瞻性研究中收集更多数据，以建立该病的标准治疗方法。
