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Sec5 和 Exo84 介导 RalA 依赖性细胞极化的不同方面。

Sec5 and Exo84 mediate distinct aspects of RalA-dependent cell polarization.

机构信息

Department of Anatomy and Cell Biology Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America.

出版信息

PLoS One. 2012;7(6):e39602. doi: 10.1371/journal.pone.0039602. Epub 2012 Jun 22.

DOI:10.1371/journal.pone.0039602
PMID:22761837
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3382198/
Abstract

Metastasis is a complex process during which several gross cellular changes occur. Cells must dissociate from the tumor mass and gain the ability to degrade extracellular matrix and migrate in order to ultimately attach and form a satellite tumor. Regulation of the actin cytoskeleton is an indispensible aspect of cell migration, and many different factors have been implicated in this process. We identified interactions between RalA and its effectors in the Exocyst complex as directly necessary for migration and invasion of prostate cancer tumor cells. Blocking RalA-Exocyst binding caused significant morphological changes and defects in single and coordinated cell migration.

摘要

转移是一个复杂的过程，在此过程中会发生几个显著的细胞变化。细胞必须从肿瘤块中分离出来，并获得降解细胞外基质和迁移的能力，才能最终附着并形成卫星肿瘤。肌动蛋白细胞骨架的调节是细胞迁移必不可少的方面，许多不同的因素都参与了这一过程。我们发现 RalA 与其效应物在胞外体复合物中的相互作用对于前列腺癌细胞的迁移和侵袭是直接必需的。阻断 RalA-胞外体结合会导致显著的形态变化和单细胞及协调细胞迁移缺陷。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee20/3382198/3f95c0922136/pone.0039602.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee20/3382198/8ba948d01b29/pone.0039602.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee20/3382198/d71455844ebb/pone.0039602.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee20/3382198/be25503feef0/pone.0039602.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee20/3382198/44ede8ea2413/pone.0039602.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee20/3382198/870ccf75f2c7/pone.0039602.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee20/3382198/3f95c0922136/pone.0039602.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee20/3382198/8ba948d01b29/pone.0039602.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee20/3382198/d71455844ebb/pone.0039602.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee20/3382198/be25503feef0/pone.0039602.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee20/3382198/44ede8ea2413/pone.0039602.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee20/3382198/870ccf75f2c7/pone.0039602.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee20/3382198/3f95c0922136/pone.0039602.g006.jpg

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