Section of Biochemistry, Faculty of Medicine, University of Brescia, Viale Europa, 11, 25123 Brescia, Italy.
Med Chem. 2012 Nov;8(6):1182-9. doi: 10.2174/1573406411208061182.
We proposed a method of synthesis to produce [11C]Choline using TRACERlab FXc module that utilized gas phase iodination. The product had radiochemical purity of 99.79 ± 0.14 % and specific activity of 45.7 ± 7.59 GBq/μmol. [11C]Choline did not have at the moment a specific monograph in European Pharmacopeia therefore we used, when possible, as quality controls reference the monograph of [18F]FDG and we proposed suitable methods to verify radiochemical purity and to quantify residual DMAE and choline amounts.
我们提出了一种使用 TRACERlab FXc 模块进行气相碘化合成 [11C]胆碱的方法。该产品的放射化学纯度为 99.79 ± 0.14%，比活度为 45.7 ± 7.59GBq/μmol。[11C]胆碱目前在欧洲药典中没有专论，因此，在可能的情况下，我们使用 [18F]FDG 的专论作为质量控制参考，并提出了合适的方法来验证放射化学纯度，并定量残留的 DMAE 和胆碱含量。
