Loeper J, Goy-Loeper J, Rouffy J
Clin Chim Acta. 1979 Oct 15;98(1-2):19-26. doi: 10.1016/0009-8981(79)90160-8.
Cholesterol and triglyceride content of serum lipoprotein fractions isolated by ultracentrifugation have been studied in 33 healthy subjects and in 56 subjects affected by hyperlipoproteinemia of type IIa, IIb and IV. Patients with atherosclerotic disease were characterized by a general decrease of HDL cholesterol and by a negative correlation between HDL cholesterol and VLDL triglycerides; patients with type IIb and IV showed an increase of LDL lipoproteins. The increase of triglycerides in type IIb and IV was caused by elevation of VLDL triglycerides or LDL triglycerides, and the increase of cholesterol in type IIb is sometimes caused by elevation of VLDL cholesterol. It is evident that several subtypes exist within Fredrickson's classification. Patients with cerebral arterial disease when compared with patients affected by non-ischaemic disease, showed a negative and significant correlation between HDL cholesterol and total cholesterol.
通过超速离心分离的血清脂蛋白组分的胆固醇和甘油三酯含量，已在33名健康受试者以及56名患有IIa型、IIb型和IV型高脂蛋白血症的受试者中进行了研究。患有动脉粥样硬化疾病的患者，其特点是高密度脂蛋白胆固醇普遍降低，且高密度脂蛋白胆固醇与极低密度脂蛋白甘油三酯之间呈负相关；IIb型和IV型患者的低密度脂蛋白有所增加。IIb型和IV型甘油三酯的增加是由极低密度脂蛋白甘油三酯或低密度脂蛋白甘油三酯升高引起的，IIb型胆固醇的增加有时是由极低密度脂蛋白胆固醇升高引起的。显然，弗雷德里克森分类法中存在几种亚型。与非缺血性疾病患者相比，患有脑动脉疾病的患者，其高密度脂蛋白胆固醇与总胆固醇之间呈显著负相关。
