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[与健康个体相比,IIa型、IIb型、III型、IV型和V型高脂血症患者极低密度脂蛋白、低密度脂蛋白和高密度脂蛋白组分的构成]

[Composition of VLDL, LDL and HDL lipoprotein fractions in type IIa, IIb, III, IV, and V hyperlipemia patients in comparison with healthy individuals].

作者信息

Hutt V, Klör H U, Wechsler J G, Ditschuneit H

出版信息

J Clin Chem Clin Biochem. 1984 Feb;22(2):141-6.

PMID:6716054
Abstract

The chemical composition of VLDL, LDL and HDL was studied in 82 patients with primary hyperlipoproteinaemia (37 type IIa, 7 type IIb, 3 type II, 25 type IV, 10 type V) and in ten metabolically normal individuals. Lipoprotein fractions were prepared by preparative ultracentrifugation. Each fraction was analysed for cholesterol, triglycerides, phospholipids and protein. Differences between patients and normal individuals, and between the individual types of hyperlipoproteinaemia were evident in the composition of all three lipoprotein fractions.

摘要

对82例原发性高脂蛋白血症患者(37例IIa型、7例IIb型、3例II型、25例IV型、10例V型)及10名代谢正常个体的极低密度脂蛋白(VLDL)、低密度脂蛋白(LDL)和高密度脂蛋白(HDL)的化学成分进行了研究。通过制备性超速离心法制备脂蛋白组分。对每个组分的胆固醇、甘油三酯、磷脂和蛋白质进行分析。患者与正常个体之间以及各型高脂蛋白血症之间在所有三种脂蛋白组分的组成上均存在明显差异。

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