PACU and SDS, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA.
Curr Pharm Des. 2012;18(38):6291-7. doi: 10.2174/138161212803832407.
This update aims to provide an evidence based review of natural and synthetic colloids with a special emphasis on the various generations of the synthetic colloid hydroxyethyl starch. The effect of 1(st), 2(nd) and 3(rd) generation hetastarches on bleeding, coagulopathy, acute kidney injury and mortality will be discussed. The results of randomised controlled trials addressing morbidity and mortality outcomes of colloid versus crystalloid resuscitation in critically ill patients will be described. In addition, the rationale and evidence behind early goal directed fluid therapy (EGDFT) including a practical approach to assessment of dynamic measures of fluid responsiveness will be presented.
本次更新旨在提供基于证据的天然胶体和合成胶体的综述，特别强调了合成胶体羟乙基淀粉的各个代别。将讨论第一代、第二代和第三代羟乙基淀粉对出血、凝血障碍、急性肾损伤和死亡率的影响。将描述针对危重患者胶体与晶体复苏的发病率和死亡率结局的随机对照试验的结果。此外，还将介绍早期目标导向液体治疗（EGDFT）的原理和证据，包括对液体反应性的动态测量评估的实用方法。
