Department of Anesthesia, University Hospital Freiburg, Germany.
Curr Pharm Des. 2012;18(38):6182-94. doi: 10.2174/138161212803832317.
Underlying cardiovascular disease is a potentially modifiable risk factor that contributes significantly to perioperative morbidity and mortality. Reducing perioperative and long-term morbidity and mortality requires risk modifying perioperative management. This, in turn, requires preoperative identification of patients with, or at risk of having cardiovascular disease. Preoperative cardiac evaluation includes, (i) recognition and treatment of active cardiac conditions, (ii) assessment of surgical risk, functional capacity, and clinical risk factors, (iii) identification of candidates for non-invasive cardiac testing, coronary angiography and preoperative coronary revascularization, and (iv) pharmacologic management. A cardiac risk assessment algorithm is useful in guiding systematic evaluation. Although preoperative cardiac evaluation has improved during the past decades, we are not yet in the situation where we can accurately predict individual perioperative risk because the individual stress response to a given stressor, and the individual interactions between pharmacological intervention and intra- and postoperative risk factors are highly variable. Furthermore, preoperative cardiac evaluation is only one aspect of overall perioperative care. There are numerous intra- and postoperative factors which have been shown to affect overall outcome. Not all of them can reliably be predicted or modified in a way which improves outcome. However, recognition of such factors and aggressive attempts at appropriate intervention may reduce overall risk more than preoperative evaluation in isolation. Without defining and subsequently targeting intra- and postoperative risk factors, the benefit of preoperative cardiac evaluation will be limited.
潜在的心血管疾病是一种可改变的风险因素,它对围手术期发病率和死亡率有重要影响。降低围手术期和长期发病率和死亡率需要对围手术期进行风险修正管理。这反过来又需要术前识别有或有患心血管疾病风险的患者。术前心脏评估包括:(i)识别和治疗活动性心脏疾病,(ii)评估手术风险、功能能力和临床风险因素,(iii)确定是否需要进行非侵入性心脏检查、冠状动脉造影和术前冠状动脉血运重建的患者,以及 (iv)药物治疗管理。心脏风险评估算法有助于指导系统评估。尽管在过去几十年中,术前心脏评估已经得到了改善,但我们还不能准确预测个体围手术期风险,因为个体对给定应激源的应激反应以及药物干预与围术期和术后风险因素之间的个体相互作用变化很大。此外,术前心脏评估只是整体围手术期护理的一个方面。有许多围术期和术后因素已被证明会影响整体结果。并非所有这些因素都可以可靠地预测或改变,从而改善结果。然而,认识到这些因素并积极尝试适当的干预措施可能会比单独进行术前评估更能降低整体风险。如果不定义和随后针对围术期和术后风险因素,术前心脏评估的益处将受到限制。