Nuijs-Beems E M, Oosterhuis J A, Verburg-van der Marel E H, de Wolff-Rouendaal D, van Delft J L, van Best J A
Department of Ophthalmology, University Medical Centre, Leiden, The Netherlands.
Curr Eye Res. 1990 Aug;9(8):771-80. doi: 10.3109/02713689008999572.
The tumoricidal effect of hyperthermia was studied in Greene's amelanotic hamster melanoma transplanted into the anterior chamber of rabbit eyes. To achieve optimal depth penetration, hyperthermia was induced with near infrared light of 820-870 nm, during 15 minutes, at a beam diameter of 2.5-6.0 mm resulting in an intermediate level hyperthermia of 45-60 degrees C. At 45 degrees C no tumor destruction occurred, at 50 degrees C the effect varied from no destruction to total thickness tumor destruction. At 55-60 degrees C total tumor destruction with additional lens damage occurred. In comparison photocoagulation with white light revealed only necrosis up to half the tumor thickness.
在移植到兔眼前房的格林氏无黑色素仓鼠黑色素瘤中研究了热疗的杀肿瘤效果。为了实现最佳深度穿透，使用820 - 870 nm的近红外光诱导热疗，持续15分钟，光束直径为2.5 - 6.0 mm，产生45 - 60摄氏度的中度热疗。在45摄氏度时未发生肿瘤破坏，在50摄氏度时效果从无破坏到肿瘤全层破坏不等。在55 - 60摄氏度时发生肿瘤全层破坏并伴有额外的晶状体损伤。相比之下，白光光凝仅显示肿瘤厚度一半以内的坏死。
