在伴有内侧颞叶硬化的颞叶癫痫中，颗粒细胞弥散不是手术结果的预测指标。
Granule cell dispersion is not a predictor of surgical outcome in temporal lobe epilepsy with mesial temporal sclerosis.
作者信息
da Costa Neves Rafael Scarpa, Jardim Anaclara Prada, Caboclo Luís Otávio, Lancellotti Carmen, Marinho Taissa Ferrari, Hamad Ana Paula, Marinho Murilo, Centeno Ricardo, Cavalheiro Esper Abrão, Scorza Carla Alessandra, Targas Yacubian Elza Márcia
机构信息
Department of Neurology, Neurosurgery, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brazil.
出版信息
Clin Neuropathol. 2013 Jan-Feb;32(1):24-30. doi: 10.5414/NP300509.
The aim of this retrospective study of a series of patients with mesial temporal lobe epilepsy (MTLE) and mesial temporal sclerosis (MTS) was to analyze the association of granule cell dispersion (GCD) with surgical prognosis, patterns of MTS and clinical data. Hippocampal specimens from 66 patients with MTLE and unilateral MTS and from 13 controls were studied. Quantitative neuropathological evaluation was performed on NeuN-stained hippocampal sections. Patients' clinical data, types of MTS and surgical outcome were reviewed. GCD occurred in 45.5% of cases and was not correlated with clinical variable. More severe neuronal loss was observed in patients with GCD. Except for MTS Type 2 - observed only in four no- GCD patients - groups did not differ with respect to the types of MTS. Surgical outcome was similar in both groups. In conclusion, GCD was associated with the degree of hippocampal cell loss, but was not a predictor of surgical outcome.
这项针对一系列内侧颞叶癫痫（MTLE）和内侧颞叶硬化（MTS）患者的回顾性研究旨在分析颗粒细胞弥散（GCD）与手术预后、MTS模式及临床数据之间的关联。研究了66例MTLE伴单侧MTS患者以及13例对照者的海马标本。对NeuN染色的海马切片进行了定量神经病理学评估。回顾了患者的临床数据、MTS类型及手术结果。45.5%的病例出现GCD，且其与临床变量无关。GCD患者观察到更严重的神经元丢失。除2型MTS（仅在4例无GCD患者中观察到）外，两组在MTS类型方面无差异。两组手术结果相似。总之，GCD与海马细胞丢失程度相关，但不是手术预后的预测指标。
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