颗粒细胞弥散与右侧颞叶内侧癫痫的记忆障碍有关。
Granule cell dispersion is associated with memory impairment in right mesial temporal lobe epilepsy.
机构信息
Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo SP, Brazil.
出版信息
Seizure. 2012 Nov;21(9):685-90. doi: 10.1016/j.seizure.2012.07.008. Epub 2012 Aug 5.
PURPOSE
We analyzed the association of granule cell dispersion (GCD) with memory performance, clinical data and surgical outcome in a series of patients with mesial temporal lobe epilepsy (MTLE) and mesial temporal sclerosis (MTS).
METHOD
Hippocampal specimens from 54 patients with MTLE (27 patients with right MTLE and 27 with left MTLE) and unilateral MTS, who were separated into GCD and no-GCD groups and thirteen controls were studied. Quantitative neuropathological evaluation was performed using hippocampal sections stained with NeuN. Patients' neuropsychological measures, clinical data, type of MTS and surgical outcome were reviewed.
RESULTS
GCD occurred in 28 (51.9%) patients. No correlation between GCD and MTS pattern, clinical data or surgical outcome was found. The presence of GCD was correlated with worse visuospatial memory performance in right MTLE, but not with memory performance in left MTLE.
CONCLUSION
GCD may be related to memory impairment in right MTLE-MTS patients. However, the role of GCD in memory function is not precisely defined.
目的
我们分析了颗粒细胞离散（GCD）与记忆表现、临床数据和一系列内侧颞叶癫痫（MTLE）和内侧颞叶硬化（MTS）患者手术结果的相关性。
方法
对 54 例 MTLE 患者（27 例右侧 MTLE 和 27 例左侧 MTLE）和单侧 MTS 的海马标本进行研究，将其分为 GCD 组和非 GCD 组，并纳入 13 例对照。使用 NeuN 染色的海马切片进行定量神经病理学评估。回顾患者的神经心理学测量、临床数据、MTS 类型和手术结果。
结果
28 例（51.9%）患者发生 GCD。GCD 与 MTS 模式、临床数据或手术结果之间无相关性。GCD 的存在与右侧 MTLE-MTS 患者的视觉空间记忆表现较差相关，但与左侧 MTLE 患者的记忆表现无关。
结论
GCD 可能与右侧 MTLE-MTS 患者的记忆障碍有关。然而，GCD 在记忆功能中的作用尚未明确界定。
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