利用卷枝毛霉变种进行生物转化生产新型吡啶 N-氧化物。
Production of a new pyridine N-oxide by bioconversion with Cunninghamella echinulata var. elegans.
机构信息
Department of Biological Engineering, Utah State University, 4105 Old Main Hill, Logan, UT 84322-4105, USA.
出版信息
J Biosci Bioeng. 2012 Nov;114(5):497-9. doi: 10.1016/j.jbiosc.2012.06.006. Epub 2012 Jul 3.
PMID:22762974
Abstract
A new N-oxide was produced from 3-(N-Boc-aminomethyl)-5-bromopyridine by bioconversion with Cunninghamella echinulata var. elegans ATCC 9245, and its structure was established based on the spectral data. The microbial N-oxidation is efficient and highly selective. The substrate was transformed into the product in 7 days.
摘要
新型 N-氧化物是由 3-(N-Boc-氨甲基)-5-溴吡啶经卷枝毛霉（Cunninghamella echinulata var. elegans ATCC 9245）生物转化得到的，其结构是基于光谱数据确定的。微生物 N-氧化高效且具有高选择性。在 7 天内，底物完全转化为产物。
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