Keeler J R, Hurt H H, Nold J B, Lennox W J
U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 21010.
Drug Chem Toxicol. 1990;13(2-3):229-39. doi: 10.3109/01480549009018123.
In all species previously studied, inhalation of toxic doses of phosgene results in varying degrees of pulmonary edema, often after a symptom-free period. The sheep is an anatomically unique animal in which to study the development of pulmonary edema by monitoring the effluent from a catheterized caudal mediastinal lymph node. In addition, the size of the sheep is sufficient to permit placement of vascular monitoring devices and withdrawal of multiple biologic samples for analyses. In spite of this, there appear to be no published reports of sheep having ever been exposed to phosgene. This study was undertaken as a dose-ranging study, in order to permit subsequent studies of phosgene inhalation toxicity in a sheep lung lymph preparation. Accordingly, the LCt50 (24 hours) was estimated to be 13,300 mg.min/m3 (3325 ppm) by "up and down" subsequent dosage selection and moving average interpolation methods.
在所有先前研究过的物种中，吸入毒性剂量的光气会导致不同程度的肺水肿，通常在一段无症状期之后出现。绵羊在解剖学上是一种独特的动物，通过监测经导管插入的后纵隔淋巴结的流出液来研究肺水肿的发展。此外，绵羊的体型足以允许放置血管监测装置，并采集多个生物样本进行分析。尽管如此，似乎没有关于绵羊曾接触光气的公开报道。本研究作为一项剂量范围研究开展，以便随后在绵羊肺淋巴制剂中研究光气吸入毒性。因此，通过“上下”后续剂量选择和移动平均插值法，估计LCt50（24小时）为13300毫克·分钟/立方米（3325 ppm）。
